Energetic Chemistries
SK pharmteco has extensive expertise in commercial-scale production using highly energetic chemistries. Our toolbox offers a rich palette of clean, reliable, and scalable reactions. Energetic chemistries often offer a clean and efficient synthetic route and can be scaled safely at our facilities using specialized process development expertise and processing technologies. The development and production of energetic chemistries at SK pharmteco can be performed at laboratory to commercial scales under CGMP-compliant conditions.
SK pharmteco approaches evaluation, development, and scale-up of energetic chemistries with a combination of process hazard evaluation, process development techniques, and specialized technology to ensure safe and reliable production.
Process Hazard Evaluation
- Thermal Decomposition Analysis
- Ranging Tests to Determine Safe Processing Control Limits
- Reaction Calorimetry
- Monitoring of Hazardous Reagents, Products, and By-products
- Process Hazard Analysis Prior to Each Stage of Scale-Up
Process Development
- R&D facility
- Remotely operated development bays
- Batch, CSTR, or Tube Reactor demonstration
- Specially designed continuous skid
- Kg scale batch hydrogenation
Specialized Energetic Batch Manufacturing Facilities
SK pharmteco has specially engineered facilities for conducting energetic chemistries:
- Azide Rated Pilot Facilities (100-500 gal) (0.38-1.89 m³) and Production Lines (1,500-2,000 gal) (5.68-7.57 m³)
- Continuous Diazomethane Generation Capability at Commercial Scale
- Commercial Scale Experience with Aziridines, Hydrazines, Azides, Diazomethane, Isocyanates, and Other Diazo Chemistries
Specialized Experience in the Following Energetic Chemistries
- Aziridines
- Hydrazine
- Sodium Azide
- Diazomethane
- Other Diazo Chemistries (Ethyl Azidoacetate, Ethyl Diazoacetate)
| Technology | Example |
|---|---|
| Azide | Sodium azide, hydrazoic acid |
| Diazo | Diazomethane, ethyl diazoacetate |
| Aziridines | Ethylene Imine, methyl aziridine |
| Nitrations | Mixed acids, acetyl nitrate |
| Isocyanates | Methyl isocyanate |
| Ozone | Continuous or batch ozonolysis |
| Hydrogenation | Batch and continuous |
| Others | Sodium cyanide, hydrazine, phosgene, halogenated solvents, benzene, Pyrophoric reagents |
Specialized Energetic Batch Manufacturing Facilities
SK pharmteco has specially engineered facilities for conducting energetic chemistries:
- Azide Rated Pilot Facilities (100-500 gal) (0.38-1.89 m³) and Production Lines (1,500-2,000 gal) (5.68-7.57 m³)
- Continuous Diazomethane Generation Capability at Commercial Scale
- Commercial Scale Experience with Aziridines, Hydrazines, Azides, Diazomethane, Isocyanates, and Other Diazo Chemistries
