Particle Engineering

Particle engineering focuses on modifying the physical properties of small molecule intermediates and APIs — including particle size, shape, and polymorphic form — to improve solubility, stability, and bioavailability. These modifications also enhance consistency and performance during manufacturing and formulation.

Controlling particle size directly influences solubility, dissolution rate, filtration, and downstream processability. A consistent particle size distribution ensures uniformity in dosage and reliable product performance across development and commercial scales.

We use controlled crystallization and integrated milling approaches to achieve defined polymorphs and uniform particle size distribution. Our processes manage parameters such as supersaturation, temperature, and solvent ratios to optimize yield, purity, and product isolation.

We offer a broad range of size-reduction technologies, including wet, pin, ball, hammer, co-, and jet mills. These options allow precise control over particle size to meet the requirements of different materials and process stages.

Yes. Our team develops and refines spray-drying processes under non-CGMP conditions to address API solubility challenges. These processes can be adapted as needed to support further development and scale-up activities.

We provide comprehensive material analysis, including particle size measurement, identification, polymorph screening, and solid-state characterization. These studies help establish the relationship between physical attributes and product performance, guiding process optimization.

Yes. Our crystallization, milling, and analytical expertise ensures reproducible, scalable processes that maintain solid-state control and product quality through development and commercial manufacturing.