Small Molecule Specialties

SK pharmteco applies a balanced approach to chemistry and engineering to safely scale energetic reactions from lab to commercial scale. Our specialized facilities, in-house process safety lab, and expert team evaluate risks and implement controls that prioritize safety while minimizing disruptions to keep programs on track. We support a wide range of transformations, including reductions, cross-couplings, azide/diazo chemistry, oxidations, amide bond formation, and chlorination, offering customized batch and continuous flow solutions at any scale.

Our facilities are designed for the safe development and manufacture of highly potent APIs (HPAPIs), ensuring product integrity, quality, and compliance through robust containment systems, strict operational protocols, and highly trained personnel. With a dedicated process safety laboratory on-site, our processes can be scaled quickly and efficiently. Our expert team can synthesize HPAPIs with occupational exposure limits (OEL) as low as 10 ng/m³.

Our particle engineering and material science solutions span crystallization, milling, micronization, spray drying, and material analysis, including characterization and polymorph screening. We improve physical properties of small molecule intermediates and APIs through particle size control, yield optimization, impurity rejection, and enhanced solubility to support efficient process development and scale-up.

SK pharmteco is a leader in continuous flow processing, enabling efficient transition to commercial continuous processes using prequalified, modular CGMP manufacturing lines assembled in days. Our Plug & Play design supports rapid process changes and new chemical transformations, reducing production time and delivering significant cost savings through fully continuous or hybrid processes.

At SK pharmteco, we provide a systematic approach to the development of chromatographic separation processes, giving partners complete insights into the feasibility, production rate, and manufacturing costs of a batch or continuous chromatographic separation route. With decades of experience, our expert team evaluates processes with production in mind to make scale-up straightforward, cost-effective, and sustainable.

SK pharmteco has a strong legacy in catalyst design and manufacturing, specializing in optimized catalysts for continuous flow hydrogenation. Our CGMP-compliant solutions span laboratory to commercial scale, using off-the-shelf and custom in-house catalysts to deliver higher selectivity, improved impurity profiles, safer operations, and predictable, cost-effective small molecule synthesis.