Small Molecule Process Development

Optimizing small molecule processes
for success

At SK pharmteco, we recognize the need for collaboration and transparency throughout small molecule process development. Our clients are part of the process, with visibility into the key decisions that impact the long-term safety and efficiency of the pharmaceutical manufacturing process. Our comprehensive services include everything from the evaluation and design of synthetic routes to risk assessments, process and method validation, and clinical trial manufacturing –– all customized to meet your scientific, business, and regulatory needs.

Connect with an SK pharmteco process development expert

Custom Process Development Services

Complex Chemical Transformations

Our laboratories are equipped to support a wide range of development processes covering carbon-carbon and carbon-heteratom bond formation, chiral chemistry, REDOX reactions, and protecting group chemistry. We have extensive on-scale experience with highly telescoped processes.

Top-Tier Technology for Process Control

We enhance the knowledge and control of customers’ processes using our Fourier Transform Infra-Red, Lasentec Focused Beam Reflectance Measurement, Raman Process Analytical Technology capabilities, and modeling applications.

Outstanding Analytical & Regulatory Support

Robust analytical method development is a central pillar for process development, both for regulatory filings and to safeguard the quality of the therapy as it advances towards commercialization. Our analytical and regulatory experts are here to help, providing a fully integrated service.

Pharmaceutical Process Development with SK pharmteco

We bring together a diverse team of experts to design, analyze, and optimize your small molecule program. Our specialized capabilities include:

Lactamization
Mixed anhydride formation
Nucleophilic aromatic substitution
Amidation
SN2 epoxide ring-opening
Buchwald-Hartwig amination
Classical resolution
Sharpless asymmetric epoxidation
Oxygen-sensitive coupling
Heck and Vilsmeier coupling
Esterification
Hydrogenation
Red-Al reduction
Glycoside reduction
Peroxide and hypochlorite oxidation
Fleming-Tamao oxidation
Staudinger reduction
Dehydration of amide to nitrile
Allylation
Halogenation
Protecting group chemistry (acetalization, orthoester formation, de-Bocylation)

Learn more about our world-class analytical capabilities

Contact us

We’re committed to supporting your development and manufacturing needs. Complete the form and someone from SK pharmteco will be in touch shortly.